While doing a google search, I stumbled across Dethe Elza's Living Code site.
Very interesting stuff. Dethe has abandoned Interface Builder in favor of Renaissance for UI generation.
I don't agree entirely with his reasons for not using Interface Builder. However, I do find Renaissance to be quite interesting technology and Dethe's weblog reads as a good tutorial on using Renaissance and Cocoa via Python/PyObjC.
There is also a Living Code SourceForge project that contains all of the examples and source from Dethe's site.